Antispasmodic action of 1-diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxalone (P 201-1) and its inhibitory effect on cyclic 3',5'-nucleotide phosphodiesterase (PDE) activity.
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چکیده
منابع مشابه
Cyclic nucleotide phosphodiesterase 1 and vascular aging
VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often called 'synthetic', phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellula...
متن کامل3'-cyclic nucleotide 3'-phosphodiesterase
1. A spectrophotometric assay of 2':3'-cyclic nucleotide 3'-phosphodiesterase (EC 3.1.4.37) based on the use of an acid-base indicator and a buffer having identical PKa values is described. The assay is sinmple and rapid; it was particularly convenient for monitoring the enzyme activity at vat :ous stages of purification. 2. Several proteinases were examined for their ability to solubilize 2':3...
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Abstract: Denote by MI(k) the moduli space of k-instanton bundles E of rank 2 on P = P(V ) and by Zk(E) the scheme of k-jumping lines. We prove that [E] ∈ MI(k) is not stable for the action of SL(V ) if Zk(E) 6= ∅. Moreover dimSym(E) ≥ 1 if lengthZk(E) ≥ 2. We prove also that E is special if and only if Zk(E) is a smooth conic. The action of SL(V ) on the moduli of special instanton bundles is ...
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Background: Leukocytospermia is found in both fertile and infertile men with and without evidence of infections of the genital tract. However, despite extensive research done in this subject, the clinical implications of this condition remain unclear. Leukocytes are also commonly found in semen samples, and a level above 1×106/mL is considered pathologic according to WHO criteria. Non-steroidal...
متن کاملP P 1 2
In the paper, we consider the problem of computing visibility information on digital terrain models. Visibility problems on polyhedral terrains are classi ed according to the kind of visibility information computed into point visibility, line visibility and region visibility. A survey of the state-of-the-art of the algorithms for computing visibility is presented, according to the classi cation...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1975
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.23.810